Just Too Busy To Address Ribonucleotide reductase ?

The abundance of ��1 Na-K-ATPase in the MTAL decreased by 34% and 33% in 15- and 24-month-old rats, respectively (Fig.?(Fig.2D).2D). Similarly, it decreased by 58% and 40% in DCT of 15- and 24-month-old rats, respectively. While in CCD the abundance of ��1 subunit rose gradually and peaked at 24?months to 346%. Changes in the abundance of ��1 subunit of Na-K-ATPase in the distal nephron parallel those of the ��1 subunit; that is, progressively with aging, there is a significant decrease in the abundance of ��1 subunit in MTAL and DCT and an increase in CCD (Fig.?(Fig.33). Figure 3 Changes in the abundance of ��1 subunit of Na-K-ATPase selleckchem along the distal nephron in 2-, 8-, 15-, and 24-month-old rats; P?VX-770 ic50 while the activity in DCT and CCD is depicted in Table?Table7.7. In the MTAL and DCT there is a decline in enzyme activity during aging; in MTAL it decreases 15% at age 15?months and 27% at age 24?months (P? nephron and aging. The correlation is given as percentage of levels Ribonucleotide reductase in 2-?month-old rats, assigned a value of 100%. Data represent the mean and ��SEM from four independent ... Correlation between ��1 subunit protein abundance of Na-K-ATPase along the nephron with aging Changes in protein abundance of the ��1 subunit along the nephron were compared to values obtained from 2-month-old rats, and correlated with age (Fig.?(Fig.5).5). In PCT, PST, and CCD, abundance of the ��1 subunit rose in a linear fashion with age (r?=?0.83, P?