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Materials: Thirteen patients requiring extractions of 30 upper anterior teeth were enrolled in this study. They were randomized into two groups: seven patients with 15 teeth to be extracted in the test group and six patients with 15 teeth to be extracted in the control group. Hematologists collected 5?ml of bone marrow from the iliac crest of the patients in the test group immediately before the extractions. Following tooth extraction and elevation GDC-0068 purchase of a buccal full-thickness flap, titanium screws were positioned throughout the buccal to the lingual plate and were used as reference points for measurement purposes. The sockets were grafted with an autologous bone marrow in the test sites and nothing was grafted in the control sites. After 6 months, Isotretinoin the sites were re-opened and bone loss measurements for thickness and height were taken. Additionally, before implant placement, bone cores were harvested and prepared for histologic and histomorphometric evaluation. Results: The test group showed better results (PProtein Tyrosine Kinase inhibitor bone in both the control and the test groups, 42.87��11.33% (median 43.75%) and 45.47��7.21% (median 45%), respectively. Conclusion: These findings suggest that the autologous bone marrow graft can contribute to alveolar bone repair after tooth extraction. To cite this article: Pelegrine AA, da Costa CES, Correa MEP, Marques JFC Jr. Clinical and histomorphometric evaluation of extraction sockets treated with an autologous bone marrow graft. Clin. Oral Impl. Res. 21, 2010; 535�C542. doi: 10.1111/j.1600-0501.2009.01891.x ""Objectives: Implant design features such as macro- and micro-design may influence overall implant success. Limited information is currently available. Therefore, it is the purpose of this paper to examine these factors such as thread pitch, thread geometry, helix angle, thread depth and width as well as implant crestal module may affect implant stability. Search Strategy: A literature search was conducted using MEDLINE to identify studies, from simulated laboratory models, animal, to human, related to this topic using the keywords of implant thread, implant macrodesign, thread pitch, thread geometry, helix angle, thread depth, thread width and implant crestal module.