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It can be used as adjunct therapy with ICD or as the sole therapy, though second-line (20). Alternate pharmacologic therapy includes use of isoproterenol, which, by increasing the ICaL current, has proved to be useful for treating electrical storm in BrS (21). Conclusion BrS is a rare autosomal dominant genetic disorder that can cause SCA secondary to VF or VT. Southeast Asian men are more often affected. Sodium channelopathy and mild structural abnormalities of RV outflow tract are believed to be part of its underlying pathophysiology. There are three characteristic EKG patterns, but only Type 1 is diagnostic. This type can be induced by sodium channel blockers and/or Brugada EKG leads. Because fever can trigger Type 1 EKG changes precipitating dysrhythmia, febrile BrS patient should be hospitalized for continuous cardiac monitoring until a form of defibrillator is implemented. In addition, certain medications should be avoided in BrS patients. For symptomatic patients, wearable external defibrillator devices should be used until a more definitive treatment modality is established. Pharmacologic therapy is less effective, but may serve as an adjunct in treatment. ICD is the only proven effective treatment modality. Conflict of interest and funding The authors declare no conflicts of interest.""The dental profession has expanded the preventive dentistry concept into prosthodontics, to bring about the MG-132 datasheet prescription called ��The Overdenture��. Preventive prosthodontic principles emphasise the importance of any procedure that can delay or eliminate further prosthodontic problems. The overdenture is a logical method for the dentist, to use in preventive prosthodontics even when few natural teeth are remaining. Many studies have also reported significant reduction in mandibular bone loss with the use of overdentures.1 2 The advantage of retaining the roots even when few in number are directional sensitivity, dimensional perception, proprioception, salivary secretion, tactile sensitivity to load, periodontal ligament support, improved occlusal force and chewing efficiency.3 A patient wearing an overdenture also has increased speed of controlled mandibular movements. The problems associated with overdenture treatment are usually caries and periodontitis of the abutment teeth which support it.4�C7 An important aspect of using copings for overdenture is the proper case selection. It is important for long-term success of the prosthesis that, the patient is highly motivated and educated about the preventive measures to be taken to prevent caries and periodontitis of the prepared abutment. Because the overdenture covers the abutment and the potential of salivary buffering is reduced, the risk of caries is increased. Case presentation A male patient, aged 67?years, came to the outpatient department with a difficulty in mastication owing to loss of natural teeth.