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, 2000). These observations may have similar sensorimotor origin as suggested for the current coherence between MEG and the hand-action-related check details peripheral signals. Thus, the EMG signal seems to provide a good estimation of the time courses of the motor and sensory events responsible for the MEG coherence as is the case for acceleration, force, and pressure signals. For the current fast repetitive hand actions, we were not able to determine consistent delays between the hand-action-related peripheral signals and the MEG signals and thus could not estimate consistent latencies for the sensory input to cortex and/or the cortical motor output to the muscle. Thus we were not able to pinpoint the relative contributions of afferent and efferent pathways to the observed coherence. However, our recent study showed strong CKC during passive finger movements (Piitulainen et al., 2013) suggesting that CKC may reflect primarily the afferent sensory input from the periphery to the cortex. The magnetic field patterns were adequately explained by single Angiogenesis inhibitor current dipoles for all subjects, tasks, and peripheral signals (see Table?2). At the level of individual subjects, the cortical sources of coherent activity were typically located at or close to the ��hand knob�� of the M1 cortex (Yousry et al., 1997) or slightly posterior to central sulcus at the primary sensory (S1) cortex. At group level, the sources were located at the same regions in the MNI brain. The M1 cortex seems to have an important role in the generation of the coherent activity. In monkeys, neuronal spiking and low-frequency (flupentixol (Bansal et al., 2011). Therefore, the low-frequency cyclic M1 cortex activity could potentially drive the coherence during repetitive hand-actions. The M1 cortex is important in the generation of the motor commands, but it also receives proprioceptive input with similar short latencies as the S1 cortex does (Devanandan and Heath, 1975?and?Lucier et al., 1975). Therefore, although the coherent sources were partly located at M1 cortex, they can also reflect sensory feedback from the moving hand. To date, functional magnetic resonance imaging (fMRI) has been the main tool in the non-invasive presurgical evaluation of the SM1 cortex (Bartsch et al., 2006?and?De Ti��ge et al., 2009). Unfortunately, interpretation of fMRI maps is challenging in patients with altered neurovascular coupling caused by various brain disorders (Bartsch et al., 2006, D'Esposito et al., 2003, Korvenoja et al., 2006?and?Krings et al., 2001). In such patients, MEG may represent an alternative to fMRI as it provides direct information about neuronal activity. MEG may be superior to fMRI in some patients with space-occupying lesions for central sulcus identification (Korvenoja et al., 2006?and?M?kel? et al.