Phosphorylation Of Gpcr

Acknowledgments The authors would prefer to thank Ms. Katie Lee for her assistance. SC would be the Canada Study Chair inside the Genetics of Obesity and Diabetes and also a Michael Smith Foundation for Health Analysis Scholar. Author Contributions Conceived and designed the experiments: SMC. Performed the experiments: MMH XH SK. Analyzed the information: MMH SMC. Contributed reagents/materials/analysis tools: JDJ. Wrote the paper: MMH SMC. Revised the manuscript: JDJ. References 1. Weir GC, Bonner-Weir S 5 stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes 53 Suppl 3: S1621. two. Lyssenko V, Laakso M Genetic screening for the risk of form 2 diabetes: worthless or worthwhile Diabetes Care 36 Suppl 2: S120126. three. Florez JC Newly identified loci highlight beta cell dysfunction as a key reason for type 2 diabetes: where are the insulin resistance genes Diabetologia 51: 11001110. four. Morris AP, Voight BF, Teslovich TM, Ferreira T, Segre AV, et al. Largescale association evaluation delivers insights in to the genetic architecture and pathophysiology of form 2 diabetes. Nat Genet 44: 981990. five. Stahl EA, Wegmann D, Trynka G, Gutierrez-Achury J, Do R, et al. Bayesian inference analyses on the polygenic architecture of rheumatoid arthritis. Nat Genet 44: 483489. 6. Clee SM, Attie AD The genetic landscape of sort 2 diabetes in mice. Endocr Rev 28: 4883. 7. Bhatnagar S, Oler AT, Rabaglia ME, Stapleton DS, Schueler KL, et al. Positional cloning of a variety two diabetes quantitative trait locus; tomosyn-2, a adverse regulator of insulin secretion. PLoS Genet 7: e1002323. eight. Clee SM, Yandell BS, Schueler KM, Rabaglia ME, Richards OC, et al. Positional cloning of Sorcs1, a kind two diabetes quantitative trait locus. Nat Genet 38: 688693. 9. Goodarzi MO, Lehman DM, Taylor KD, Guo X, Cui J, et al. SORCS1: A Novel Human Kind 2 Diabetes Susceptibility Gene Recommended by the Mouse. Diabetes 56: 19221929. ten. Dokmanovic-Chouinard M, Chung WK, Chevre JC, Watson E, Yonan J, et al. Positional cloning of ��Lisch-Like, a candidate modifier of susceptibility to type two diabetes in mice. PLoS Genet four: e1000137. 11. Scherneck S, Nestler M, Vogel H, Bluher M, Block MD, et al. Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL. PLoS Genet 5: e1000541. 12. Keane TM, Goodstadt L, Danecek P, White MA, Wong K, et al. Mouse genomic variation and its impact on phenotypes and gene Gpcr Biology regulation. Nature 477: 289294. 13. Roberts A, Pardo-Manuel de Villena F, Wang W, McMillan L, Threadgill DW The polymorphism architecture of mouse genetic sources elucidated making use of genome-wide resequencing data: implications for QTL discovery and systems genetics. Mamm Genome 18: 473481. 14. Aylor DL, Valdar W, Foulds-Mathes W, Buus RJ, Verdugo RA, et al. Genetic evaluation of complex traits within the emerging Collaborative Cross. Genome Res 21: 12131222. 15. Sanger Institute Mouse Genomes Project. http://www.sanger.ac.uk/ resources/mouse/genomes/. Accessed 2010 February 24. 16. Collaborative Cross Consortium The genome architecture of your Collaborative Cross mouse genetic reference population. Genetics 190: 389 401. 17. Lee KT, Karunakaran S, Ho MM, Clee SM PWD/PhJ and WSB/EiJ Mice Are Resistant to Diet-Induced Obesity But Have Abnormal Insulin Secretion. Endocrino