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Pathologically, hyaline membrane formation and intra-alveolar hemorrhage were observed in all cases. Conclusion?Severe epithelial damage was determined as the main mechanism of respiratory failure caused by influenza A/H1N1pdm virus infection. YUN SEONG KIM1, WOO HYUN CHO1, SEUNG EUN LEE1, DOO SOO JEON1, BYUNGHEE LEE1, BONG SOO SON2, DO HYUNG KIM2 1Department of Internal medicine, Pusan National University DDR1 Yangsan Hospital, Yangsan, Korea, 2Department of Cardiovascular and Thoracic Surgery, Pusan National University Yangsan Hospital, Yangsan, Korea Lysophosphatidylcholine (LPC) is a novel inflammatory lipid mediators, which has been suggested as an important biomarker to predict sepsis related mortality. Previous studies showed that decreased LPC concentration is associated with sepsis related mortality. this website So, we investigated serum LPC level in community acquired pneumonia to predict outcome and analyzed correlations between serum concentration and clinical parameters. We prospectively collected blood samples from patients who were diagnosed of community acquired pneumonia in Pusan national university yangsan hospital from August 2011 to February 2013. All blood samples were obtained initially (D1) and 7 day (D7) after. Obtained samples were immediately centrifuged and plasma was stored at ?80 degree Celcius within 2 hour. We checked plasma LPC levels using ANZWELL LPC Assay Kit (Alfresa Pharma Corporation, Japan) which is an commercial enzymatic assay kit. We retrospectively reviewed medical records of patients and analyzed correlations between plasma LPC levels and clinical parameters such as pneumonia severity index (PSI), CURB65, simplified acute physiology score II (SAPS II). Forty five patients with community acquired pneumonia were included in this study. The mean PSI, CURB65 and SAPS II were 96.27?��?41.374, 1.78?��?1.363 and 34.47?��?21.288, respectively. The mean serum LPC concentrations at day 1 and day 7 were 57.88?��?43.42?umol/L and 72.60?��?58.04?umol/L, respectively. The serum LPC concentration at D7 was significantly Transmembrane Transporters inhibitor lower in non-survivor group (16.07?��?30.83?umol/L vs 92.39?��?52.15?umol/L, p?