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Rates of hospitalisation for asthma exacerbations and trends in these rates over time are different in adults and children with the patterns varying by sex, season and environmental conditions. This article is protected by copyright. All rights reserved. ""In asthma, the airway inflammatory phenotype influences clinical characteristics and treatment response. Although induced sputum is the gold standard test for phenotyping asthma, a more accessible method is needed for clinical practice. To investigate whether white blood cell counts and/or their derived ratios can predict sputum eosinophils or neutrophils in uncontrolled asthma. This cross-sectional selleck screening library study evaluated 164 treated but uncontrolled asthmatic patients with sputum induction and blood collection. Receiver-operating characteristic (ROC) curves were used to assess the relationship between blood and sputum parameters. There was a significant positive relationship between blood eosinophil parameters and the percentage of sputum eosinophil count. A weak but significant correlation was found between sputum neutrophil percentage and blood neutrophil percentage (r?=?0.219, P?=?0.005). ROC curve analysis identified that blood eosinophil percentage count was the best predictor for eosinophilic asthma, with an area under the curve NLG919 order (AUC) of 0.907 (P?LMTK2 (NK) cells have been implicated in the development of allergic airway inflammation. However, the in vivo role of NK cells has not been firmly established due to the lack of animal models with selective deficiencies in NK cells. To determine the specific contribution of NK cells in a murine model of allergic airway disease (AAD). The role of NK cells in AAD was studied using NK-deficient (NKD) mice, perforin?/? mice, and mice depleted of Ly49A/D/G+ NK cell subsets in an ovalbumin-induced model of allergic airway disease (OVA-AAD). Induction of OVA-AAD in C57BL/6 wild-type (WT) mice resulted in the expansion of airway NK cells and the development of pronounced airway eosinophilia.