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1?cm. An accurate head circumference measurement is produced by placing a non-stretchable tape around the mid-forehead and most prominent portion of the occiput in such a way that the maximum circumference is obtained. Comparison between Egyptian DS patients and normal Egyptian controls was performed. Subjects were divided into male and female groups and sub-grouped into age groups (1 month apart), ranging from birth to 36 months. Means and standard deviation (SD) of evaluated growth measurements were calculated for each age and sex separately. They were graphically smoothed using polynomial fitting equation and plotted. Also, means for the three anthropometric measures comparing male and female Down syndrome patients with normal children were graphically plotted Transducin using polynomial equation for smoothing. Cubic splines, Kernel regression, and locally weighted find more regression methods were used for smoothing data. After comparison of these methods, locally weighted regression was selected and applied to the data set. Baker et al. [1992] found that polynomial curves adequately represent growth pattern. We plotted growth curves of weight, length and head circumference from age 0�C36 months with means and ��1 and 2 SDs. Statistical analysis of data was carried out using SPSS software (version 16). Based on age and sex, the data were divided into monthly intervals from birth till 36 months. Means and SDs were calculated for the male and female groups. Student's check details t-test was used to compare the mean weight, length and head circumference at all age intervals between the two sexes, and between the two sexes of this study and the normal Egyptian controls. P-values