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Another important bias can arise from the questionnaire length and respondents fatigue. Therefore, we kept the length of the questionnaire to no more than 20 minutes to complete. Results The response rate was 96%, with 229 total responses from among the 260 students who received the questionnaire form. None of the questionnaires was disqualified. The respondents age was 26.42 �� 2.75 and 96 were males (43.2%). One hundred and five students were in their pre-clinical years (years 1�C3), comprising 45.9% of the cohort, while MG-132 ic50 the remaining 114 students were in their clinical studies (years 4�C6). Out of the 229 students included in the analysis, 39 had taken MPH at least once, while 198 did not use MPH. Out of the MPH users, 31 had taken MPH during ATPase the year prior to the study and were considered active users, while 8 students had not used MPH during the 12 months prior the survey. Cumulative incidence of MPH use throughout medical school is demonstrated in Figure 1, which shows the distribution of onset times of drug use at each phase of medical school. It is notable that the major increase in the use rate was prior to the medical school and during other academic studies (4% raise). In the first year, about 6% of the students use MPH, during medical school the rates climb gradually with a significant increase in the third year, from 10% to 14%. By the end of the sixth year we can see a usage rate of 18%. A Venn diagram presented in Figure 2 shows the intersection of the three main groups among the study's participants: Students diagnosed with ADD; students with positive ASRS test; and students who use MPH regularly. Twenty-two students had formal ADD diagnosis and 52 students had positive ASRS-S score, yet only 13 students were ASRS positive and diagnosed with ADD. The 39 users are presented in the circle below with 20 of them diagnosed with ADD (out of which 13 also had positive ASRS-S score) and 7 more had a positive ASRS-S score but no formal ADD diagnosis. Baseline characteristics of those who used MPH during the last 12 months are depicted in Table 1. Active MPH users were older, compared with non-active ones (28.13 �� 3.45 vs. 26.14 �� 2.52 respectively, P = 0.001) and self-estimated their grades in the previous year lower than those Epacadostat in vitro who did not use MPH (81.31 �� 5.93 vs. 85.72 �� 5.08, respectively, P