Some Close-Guarded Methods Of The GPX5 Revealed

10, 11, 14, 15?and?30 Supporting the association between the injury severity and the development of hypothermia described in previous studies,10, 11, 14, 16?and?17 we found a significantly increased ISS in hypothermic patients compared to non-hypothermic patients (p?=?0.048). In accordance to previous studies, 10?and?20 hypothermic patients suffered more often from severe traumatic brain injuries (TBI) in the present study. In this context, these results support impaired thermoregulation due to damage to thermo-regulative, hypothalamic areas as one cause of accidental hypothermia. In contradiction, Steinemann et al. reported no differences concerning TBI between hypothermic and non-hypothermic trauma patients. 7 Hypothermic patients received significantly more blood products compared Vorinostat to non-hypothermic patients in the present study (p?SB203580 manufacturer to increased injury severity. Accordingly, Beilman et al. described a significantly increased transfusion rate of PRBCs in case of hypothermia. 11 In contrast, Ireland et al. found no difference in transfused blood products depending on the presence of hypothermia. 10 In the study of Ireland et al., the overall injury severity as well as the injury severity of the hypothermic and non-hypothermic subgroup was lower compared to the investigation of Beilman et al. 11 and our study. As we found the ISS (PRBC: p-value 0.0055, OR 1.349; FFP: p-value 0.033, OR 1.655; PLT: 0.005, OR 2.040) to be an independent factor for the transfusion of blood products, this might be an explanation for the missing differences concerning transfused blood products in the aforementioned study. 10 Despite a significantly increased mortality rate in hypothermic patients compared to non-hypothermic patients (p?=?0.02), multivariable analysis with logistic regression demonstrated hypothermia not to be an independent factor of mortality (p-value 0.138, GPX5 OR 1.958) in the present study. These observations are in accordance with previous studies 7?and?11 suggesting that increased mortality in hypothermic trauma patients is primarily caused by injury severity and does not reflect an independent adverse effect of hypothermia. In contrast, several studies found accidental hypothermia to be an independent factor of mortality in multiple trauma patients. 10, 18, 19?and?20 However, comparison of data is difficult due to differences in study population characteristics and inclusion of confounding factors. In comparison to the present study, Ireland et al. included less severely injured and secondarily transferred patients. 10 In order to prevent a bias due to in-hospital interventions conducted by the referral department, we excluded secondarily transferred patients.