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2.6. Statistical Analysis Statistical analysis was performed using CSS Statistica for Windows (version 10) software (Stat-Soft Inc., Tulsa, OK, USA, 2010). The Mann-Whitney U-test and the Kruskal-Wallis test were used for nonparametric, unpaired samples, and the Kaplan-Meier and allobarbital log-rank tests were used for overall survival analysis and logistic regression in a multivariate analysis to assess the differences between the investigated groups. Additionally, correlations were calculated using Spearman��s rank correlation test. Differences between samples were considered significant at p (102.050 �� 17.247 vs. 227.963 �� 304.858 �� 106 cells/L, p = 0.009); (II) a greater proportion of patients that were on intravenous IgG support during the first 100 days post-HSCT (19/33 vs. 23/63, p = 0.048); and (III) AZD2014 a higher risk of herpes virus reactivation (21/47 vs. 12/50, p = 0.032) and that of aGvHD (20/33 vs. 23/64, p = 0.020). Blood work revealed that the above group of patients receiving a graft from anti-CMV-IgG negative donors had lower proportions and numbers of CD4+CD25high lymphocytes (0.374% �� 0.030% vs. 0.503% �� 0.041%, p = 0.036; 1.589 �� 0.218 �� 106 vs. 3.456 �� 0.436 �� 106 cells/L, p = 0.003, Figure 1A) as compared to their counterparts grafted from CMV IgG positive donors. Figure 1 Numbers of CD4+CD25high lymphocytes in the blood determined at the beginning of hematologic recovery in groups of patients stratified according (a) to their anti-CMV IgG donor serostatus (b) and with or without herpes virus (cytomegalovirus (CMV), Epstein�CBarr ... Proportions and counts of CD8+ and CD16+CD56+ lymphocytes in the blood at hematologic recovery were investigated against donor anti-CMV-IgG CMV serostatus. It was found that the selleck chemical proportions (29.512% �� 1.741% vs. 22.514% �� 2.019% p = 0.041) and at the trend level the numbers of CD8+ lymphocytes (240.867 �� 34.251 �� 106 cells/L vs. 96.850 �� 13.001 �� 106 cells/L p = 0.062) were higher in patients receiving grafts from anti-CMV-IgG seropositive donors as compared to those grafted from anti-CMV-IgG negative donors, but not when CD16+CD56+ lymphocytes were considered. Interestingly, an increased risk of herpes virus reactivation (CMV, EBV, and/or HHV6) was associated with reduced levels of CD4+CD25high lymphocytes in the blood (2.180 �� 0.349 �� 106 cells/L vs. 3.482 �� 0.477 �� 106 cells/L, p = 0.006; 0.370% �� 0.030% vs. 0.539% �� 0.045%, p