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Figure 1 contrasts protein expression between the thoracic aorta, carotid, brachial, femoral, renal and right coronary arteries with respect to eNOS, HSP90, p67phox, SOD1 and SOD3 content. Expression of eNOS was higher in the carotid artery than in thoracic aorta, brachial and renal arteries, while HSP90 expression was lower in the renal artery than in the carotid, femoral and right coronary arteries (all P Resiquimod P LEE011 order brachial and renal arteries (both P learn more we evaluated endothelial cell phenotype in the straight segments of arteries and veins. Swine represent an optimal model for the study of vascular physiology and vascular cell biology because of the similarities between humans and pigs in coronary anatomy, vascular structure (layers of smooth muscle) and systemic haemodynamics (Turk & Laughlin, 2004). The primary finding of this study was the marked heterogeneity in the expression of both pro- and anti-atherogenic markers across the vasculature, at both the protein and the transcriptional levels.