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Subsequently, the ROIs were then transformed automatically to the susceptibility maps using an affine registration and transformation algorithm from FSL (Smith et al., 2004). Statistical analyses were performed using STATISTICA 7.1 (StatSoft, Tulsa, USA) and a p�\value below 0.05 was considered as statistically significant. Linear regression models were employed to investigate the relation between chemically determined iron concentrations and bulk tissue susceptibility. All statistical analyses were first carried out for all brain regions, and then for gray and white matter regions separately. Iron concentrations were obtained from 457 specimens (172 from deep gray matter and 285 from white matter structures). From one subject only one hemisphere was dissected and accidentally contaminated samples were excluded. The mean wet weight of the tissue specimens was 0.62?g (standard deviation: 0.36?g). Inductively coupled plasma mass spectrometry U0126 purchase revealed the highest mean iron concentration in the globus pallidus, followed by the putamen, the caudate nucleus, and the thalamus. The LMTK2 iron concentrations were in line with previous post mortem work (Hallgren and Sourander, 1958) and all mean iron concentrations in white matter were lower than in the deep gray matter structures (Table?1). The analysis of the formaldehyde solution before and after the fixation process did not reveal any iron content, indicating that no leakage of tissue iron into the buffer solution had occurred. The visual appearance of susceptibility maps (Fig.?2) was in line with previous QSM work, although visibility of small vessels was substantially increased, which may be attributed to the increased deoxygenation level of the blood. The results of the regional QSM analysis are summarized in detail learn more in Table?1 where positive and negative values represent paramagnetic and diamagnetic magnetic susceptibilities, respectively, relative to occipital white matter. All deep gray matter structures were paramagnetic relative to white matter structures. Regional magnetic susceptibilities were highly correlated with the results from mass spectrometry, in particular with higher iron concentrations. Fig.?3 illustrates the strong positive linear correlation found between chemical iron concentration and bulk magnetic susceptibility when all regions were included in the analysis (r?=?0.87, p?