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4%, p AZ191 PD patients had similar everyday functioning measured by the SES (75.0 �� 16.2 versus 74.1 �� 19.4 points, p = 0.636, Table 2), female patients had worse HRQoL than males (EQ-5D index value: 0.620 �� 0.240 versus 0.663 �� 0.229, p = 0.026 and PDQ-39 SI: 27.1 �� 17.0 versus 23.5 �� 15.9, p = 0.010). Out of the PDQ-39 components, ��Mobility,�� ��Emotional well-being,�� ��Social support,�� and ��Bodily discomfort�� had higher impairment in women, whereas the section of ��Communication�� was worse in men. 3.6. Determinants of HRQoL in PD Multiple regression analysis was performed to estimate the PDQ-39 SI based on various clinical factors. Due to collinearity, age of disease onset, MDRS, and MMSE scores were excluded from the regression analysis (tolerance Apoptosis Compound Library datasheet (importance = 0,53; �� = 0.883, p (coded as 1 = males and 2 = females, importance = 0.06; �� = ?3.389, p = 0.010), ME part of MDS-UPDRS (importance = 0,05; �� = ?0.134, p = 0.012), SES (importance = 0.04; �� = ?0.124, p = 0.017), UDysRS total score (importance = 0.03; �� = 0.166, LGK-974 in vitro p = 0.013), HAM-A total score (importance = 0.03; �� = 0.258, p = 0.019), ACE total score (importance = 0.03; �� = ?0.118, p = 0.027), QUIP total score (importance = 0.02; �� = 0.667, p = 0.029), and ESS total score (importance = 0.02; �� = 0.186, p = 0.038) explain the highest significant amount of variance in the value of the PDQ-SI score (intercept = 22.433, F(9,593) = 120.400, p 0.006, p