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Its quantification relies on the visual estimation of percentile hepatocytes that have the macrovesicular or microvesicular lipid vacuoles. Range of fat fractions in the liver Range of fat fractions was defined as the difference between the maximal value and the minimal value among the 13 measured fat fractions in the liver. Range Talazoparib order of fat fraction in the whole liver according to the peripheral fat deposit Individual range of fat fraction according to the fat fraction in peripheral region of S5 (biopsy site) was analyzed to predict the change of fat accumulation pattern on the amount of peripheral fat deposit. Statistical analysis Correlations between the estimated fat fraction using CSI, the histologic degree CAPNS1 of macrovesicular fatty change in the biopsy, and the range of fat content in the 13 ROIs were assessed with Pearson correlation, the paired t-test, linear regression, and analysis of variance (ANOVA). After analysis with repeated measures of ANOVA, Bonferroni adjustment was applied to control for type I error. All statistical analyses were performed using commercial software IBM SPSS Statistics ver. 19.0 (IBM Co., Armonk, NY, USA). A P-value of ��0.05 was considered significant. RESULTS The mean age of donors was 31.9 (standard deviation [SD], 11.4) years and mean BMI was 23.7 (SD, 2.7) kg/m2. Male gender was predominant (75.3%) and mean macro-vesicular fat change was 3.24% (SD, 4.6) on liver biopsy. www.selleckchem.com/products/s-gsk1349572.html Table 1 shows the average estimated fat fraction in all 13 regions using CSI. The estimated fat fraction in the peripheral region of S5, where liver wedge biopsy was performed during donor operation, correlated well with the amount of macrovesicular fatty change in the biopsy samples (r = 0.816, P 1 Average fat fraction in each segment (S) relative to the fat quantification on liver biopsy There was a significant difference in fat fractions between the peripheral and deep regions of S4, S6, S7, and S8, with a higher fraction peripherally: S4 (3.8% �� 2.7% vs. 3.1% �� 2.8%, P