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The estimates for these analyses are interpreted as the difference between randomised groups adjusted for baseline. Applications per day were analysed by analysis of variance (ANOVA) with the response variable as the mean average number of applications per day, predictor variable randomisation group, and using the number of days in the trial as a weight, to account for variations in the number of days of application. In a post hoc analysis, the proportion of participants in whom the IGA-RSS was zero (clear of rosacea) at week 8 was calculated. SAS V.9.3 was used. Results The flow of participants in the study is shown in figure 1. There were 69 participants randomised to control and 69 to Honevo. One Honevo participant was subsequently excluded due to the use of a prohibited medication on enrolment, and their data was not used in the consequent analysis. The characteristics of the participants are shown in table 1. Participants were predominantly aged between 50 and 70?years, and had had rosacea for a mean of 15?years. Nineteen per cent of participants in each group had previously used oral antibiotics for rosacea, while 44% and 38% had previously used any topical treatments for rosacea in the Honevo and control groups, respectively. There were 7/68 (10.3%) withdrawals in the Honevo group (3 worsening rosacea, 2 took prohibited medications, 2 for other reasons unrelated to the study) and 15/69 (21.7%) withdrawals in the control group (8 worsening rosacea, 2 took prohibited medications, 1 did not want to take the control medication, 1 found the study inconvenient, and 3 for reasons unrelated to the study). Table?1 AZD6244 price baseline characteristics of participants Figure?1 Flow of participants through trial. Primary outcome There were 24/68 (34.3%) in the Honevo group and 12/69 (17.4%) in the control group who had a ��2 improvement in IGA-RSS at week 8 compared to baseline (relative risk 2.03 (95% CI 1.11 to 3.72), p=0.020. The corresponding OR was 2.59 (1.17 to 5.74). Secondary outcomes The change from baseline in IGA-RSS for participants who did not withdraw is shown in table 2, online supplement table S3 and figure 2. The change in IGA-RSS for Honevo compared to control at week 2 minus baseline was ?1 (Hodges-Lehman estimate, 95% CI ?1 to 0, p=0.03), and at week 8 minus baseline was ?1 (Hodges-Lehman estimate, 95% CI ?1 to 0, p=0.005; table 3). The subject-rated VAS-CS at week 2 was 9.1 (CI 3.5 to 14.7), p=0.002, and at week 8 was 12.3 (CI 5.7 to 18.9), p