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75 �� 0.27 kg/cm2 (where n = 6) indicating that mini-tablets are of sufficient strength to withstand the physical attrition and impact. The % friability was Enzalutamide concentration of 6 h that was also undesirable which is shown in Figure 2. Figure 2 Dissolution profile of mini-tablets Results of stability studies The stability study of capsule containing IRG and PRM was kept at accelerated conditions (40��C and 75% RH) for the period of 1-month.[19] The evaluation was done using parameters such as appearance of capsule, while drug content and drug release of IRG and mini-tablets were checked. The Figures ?Figures3,3, ?,44 and Table 5 showed that the formulation remained stable throughout the period of 1-month. Figure 3 Dissolution profile of granules before and after stability study Figure 4 Dissolution profile of mini-tablets before and after Histone demethylase stability study Table 5 Stability study of optimized formulation Drug compatibility study by Fourier transform infrared spectroscopy The FT-IR spectra of drug + excipients shows that there were no changes in the peak of drug which suggests that there was no interaction between drug and excipients as shown in Figure 5 (Peak a-FT-IR spectra of physical mixture (Drug + excipients) overlapped with the FT-IR spectra Peak b of pure drug). Figure 5 Fourier transform Selleckchem Venetoclax infrared (FT-IR) spectra of physical mixture overlapped with FT-IR spectra of pure drug Differential scanning calorimeter study of urapidil and Eudragit S-100 The DSC study indicated that there was no endothermic reaction between drug and polymer (Eugragit S-100) used in the study as no shift of peak is observed as shown in Figure 6 (Peak [a]-DSC image of pure drug overlapped with DSC image of Peak [b]-urapidil+ Eudragit S-100). Figure 6 Differential scanning calorimeter (DSC) image of drug overlapped with DSC image of drug + polymer Analysis of urapidil Ultraviolet absorption maxima During scanning with the 100 ��g/ml of sample urapidil exhibited UV absorption maxima at 268 nm. Calibration curve of urapidil The calibration curve of Urapidil was taken in three media; HCl buffer pH 1.2, PBS pH 6.8 and PBS pH 7.4. The linearity range was between 5 and 14 ��g/ml for the entire buffer media as the solubility of urapidil is pH independent. CONCLUSION Till now for Urapidil several pharmacokinetic related articles have been described in the public domain. However, to the best of our knowledge related to formulation of Urapidil is not yet reported in India. Chronomodulated therapy using Urapidil reduces blood pressure without altering heart rate. The oral formulation is an effective choice in patients with hypertension and concomitant dyslipidaemia or type 2 diabetes mellitus, in whom the drug does not adversely affect and may improve lipid profiles and glucose metabolism.