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03; Fig.?1E). P/B-ratio in the DS-region was comparably low (p?=?0.87). Increased F-18-FDG uptake was observed in the US-plaques 8 weeks after cuff implantation (Fig.?2). Fig.?3 shows ��linear profiles�� of F-18-FDG uptake along the right (A) and left (B) CCA from the US-region tiospirone to the DS-region, analyzed by nine VOI (see Methods section and Fig.?S1, Supplemental material) stacked from US to DS (represented by segments 1�C9 in Fig.?5) 8 weeks after cuff implantation. The maximum F-18-FDG uptake is found in the US-region and in the proximal part of the cuff (segments 2�C4), whereas the more distal part of the cuff and the DS-region showed a decreasing uptake, regardless of the side of cuff implantation. In an exemplary 17-AAG supplier selection of six animals F-18-FDG uptake assessed by ex-vivo PET/CT (Fig.?S3, Supplemental material) correlated well with in-vivo PET/CT measurements (r?=?0.72, p?Docetaxel (Fig.?S7A�CC). Vessel lumen narrowing characteristically results in increased blood flow velocity at the throat of the plaque, low shear-stress in the US region and oscillatory shear stress in the DS shoulder of the plaque [12]. These conditions promote the formation of macrophage-rich, plaques US of the stenosis and more stable plaques DS [13]. In an animal model described by Cheng et?al. [3], we show that plaques developing US of a cuff show increased F-18-FDG uptake in comparison to plaques DS. F-18-FDG uptake correlated with histological patterns of the plaques. US-plaques were larger and showed a preponderance of macrophages, while DS-plaques were typically smaller and contained less macrophages. F-18-FDG uptake was significantly higher in the US-plaques than in the DS-plaques. In-vivo as well as ex-vivo F-18-FDG PET/CT confirmed the tracer accumulation being present in the US region.