Adenosine Gradually Got You All The Way Down? We Have The Perfect Solution

For each subject and each leg we quantified Selleckchem Tanespimycin the relative difference in slopes for stimulation of the ipsilateral versus contralateral hemisphere by calculating a functional connectivity ratio (FCR). The group mean FCR of the non-paretic VL was 0.55 (range 0.2�C0.83) consistent with contralateral motor control. For the paretic VL, there was greater variability in the relationship between the ipsilateral and contralateral recruitment curves (e.g., compare Fig. 1A and B); group mean FCR was 1.7 (range 0.27�C2.6), suggestive of predominantly ipsilateral motor control. Across the group, FCR values for the paretic limb were significantly higher than those for the non-paretic limb (t?=?4.8, df?=?12, p?VEGFR inhibitor correlated with walking speed (r?=??0.80, corrected p?=?0.005) and lower limb Fugl-Meyer score (r?=??0.74, corrected p?=?0.02) ( Fig. 2), such that patients with greater relative ipsilateral connectivity to the paretic leg had a slower walking speed and a poorer clinical outcome. The FCR of the non-paretic VL was not related to walking speed (r?=??0.06, corrected p?=?1) or to Fugl-Meyer score (r?Adenosine greater reliance on ipsilateral connections (from the contralesional hemisphere) compared to contralateral connections (from the ipsilesional hemisphere). FA asymmetry did not correlate with the FCR of the non-paretic limb (r?=??0.55, corrected p?=?1). There was no relationship between the FA asymmetry of the anterior limb of the internal capsule, our control ROI, and FCR (r?=?0.09, corrected p?=?1; data not shown). FA asymmetry was negatively correlated with FM score (r?=??0.78, corrected p?=?0.005) and tended to be negatively correlated with walking speed (r?=??0.68, corrected p?=?0.05) such that patients with a greater asymmetry showed slower walking and had greater functional impairment. When the four patients scanned at 3T were removed from the analysis, all significant relationships were maintained. TBSS was used to test across the group for correlations between FCR and voxel-wise measures of FA.