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The major limitations of the study are that it is a retrospective review of the data from a single center and number of patients in the study is small. However, the study population represented the patients from the state with ADAMTS12 highest maternal and fetal mortality. Conclusions The women with GFR of SB431542 concentration pressure.[3] Hence even multiple pregnancies do not affect the renal function adversely in the normal population. Pregnancy in females with normal renal function may be associated with acute kidney injury due to pre-eclampsia, acute fatty liver, hemolytic uremic syndrome, Alpelisib research buy puerperal sepsis, hyperemesis and septic abortion in normal population. The renal function generally improves postpartum in these individuals.[4,5,6] Maternal outcomes Pregnancy is unusual in females with chronic kidney disease (CKD), but when it occurs it poses a challenge both for the nephrologist and gynecologist. The number of pregnancies varies in different CKD stages with the highest number in stage 1 or 2 as shown by Singh et al. in this issue.[7] Pregnancy, when it occurs in women with CKD, is considered high risk. Unlike in normal population where pregnancy has no adverse effects on renal function, in patients with underlying renal disease pregnancy may affect maternal and fetal outcomes.[8] This is because the diseased kidneys may be unable to adapt to the normal physiologic changes of pregnancy leading to perinatal complications. Physiological increase in GFR is attenuated in moderate renal impairment and does not occur if serum creatinine is more than 2.3 mg/dl.