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6 Recent data from the European Prospective Investigation into Cancer and Nutrition study in over 334,000 European men and women suggest that twice as many deaths may be attributable to physical inactivity compared with the number of deaths attributable to obesity.7 A large prospective study Vemurafenib supplier conducted among 252,925 persons from the National Institutes of Health�CAmerican Association of Retired Persons Diet and Health Study showed that following PA guidelines was associated with a substantially lower risk of death (relative risk [RR], 0.50; 95% confidence interval [CI], 0.46�C0.54). Importantly, engaging in PA even at less than recommended levels was also related to reduced mortality risk (RR, 0.81; 95% CI, 0.76�C0.86).8 This beneficial effect on mortality was linked to the marked improvement in all cardiovascular risk factors and in particular diabetes and hypertension.8 Furthermore, it has been well demonstrated that PA is an effective nonpharmacological intervention to improve diabetes control and to reduce high blood pressure (BP) and should be an integral component of the care strategy.4,5 However in clinical practice, many patients with known T2DM and hypertension, often overweight or obese and with other comorbidities, Amiloride do not achieve recommended levels of PA, ie, at least 30 minutes of moderate PA five times a week.3,5 In the MOtivations and BarrIers to Physical Activity in patiEnts with type 2 diabetes and hypertension (MOBILE) study, we set out to examine active and inactive populations with T2DM and hypertension, and to look into the barriers and motivations to engage in PA as expressed by active and inactive patients. We assessed the proportion of patients controlled for diabetes and hypertension among the active and inactive cohorts. Ruxolitinib concentration Finally, we explored correlates for meeting the targets for glycemic and BP control and to further investigate the role of the physicians. Methods Study design and participants MOBILE was a cross-sectional, observational French study conducted during the first half of 2014. Over 6,000 physicians (about two-thirds cardiologists and one-third diabetologists [DB]) were invited to participate in the study, 317 accepted and 258 actively recruited patients. Participating physicians (cardiologists and DB) were asked to recruit six consecutive patients with T2DM and hypertension: two active and four inactive patients, on the basis of an initial screening with the Ricci-Gagnon (RG) self-questionnaire (active defined as RG total score ��16). Men and women aged ��18 years, diagnosed with T2DM and with pharmacologically treated hypertension for whom a recent glycated hemoglobin (HbA1c) value was available (