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Trials in each of the 3 conditions (Sign, Kana, and Rest) were separately convolved with the canonical hemodynamic response function by using a general linear model. A one-lag auto-regression (AR(1)) model was used to correct for serial autocorrelations. The time series was filtered using a discrete cosine-transform filter with a 128-s cut-off period. The contrast images during the Kana (TANKA) tasks were obtained by?concatenation Decitabine mw of all 4 sessions and?subtractions (post???pre). The contrast images were at a threshold of p?Selleck Metformin significant. The average number of correctly read letters for volunteers with normal vision (n=?6) was 2108?��?190, whereas that for patients (n=?6) was 981.4?��?695.6 before and 1018.7?��?523.1 after EMT, respectively ( Table 2). Although the effects of EMT on task performance (i.e., rate of change [%] in Table 2) varied between patients depending on the extent of their disease, 5 of the 6 patients showed an increase in the number of correctly read letters in 5?min of the reading task (patients 1�C5 in Table 2) after EMT. Here, we included patient 2 in the category of improved patients. Because patient 2's disease was progressive and?such patient?was?concomitantly suffering central scotoma-like retinal degradation of the left Thymidine kinase eye (see? Supplementary Fig. 1), the retained task performance (552 before EMT?vs. 553 after EMT) could be considered as a positive effect of EMT. Although?averaged task performances of the 6 patients were 46.6% (p