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A randomized controlled trial, carried out from 2012 to 2013, included 56 residents from four NHs, 36 women and 20 men (randomized into experimental and control groups). Eight participants dropped out. Participants of the experimental group underwent 14 CST sessions (7 weeks) in groups of six to eight older adults, and participants of the control group received usual care. The Montreal Cognitive Assessment, the Geriatric Depression Scale-15, and the Barthel Index of activities of daily living (ADLs) were administered at baseline and postintervention. Repeated measures revealed that CST increased cognition (F?= 8.581; p?= .005; partial �� squared?= 0.157; power?= 0.82). There were no statistically significant differences in depressive symptoms (F?= 1.090; p?= .302). Baseline BI 2536 solubility dmso level of ADLs did not affect the outcomes. CST had significantly improved Kinase Inhibitor Library cognition, explaining the 15.7% variability, but there was no statistical evidence of its effectiveness on depressive symptoms. This improvement was not affected by the baseline level of dependence-independence in ADLs. CST offers a range of activities, providing general stimulation for thinking, concentration, and memory, usually in a social setting. These results will support implementation of CST in NHs. In addition to the impact on elderly independence and autonomy, CST may also have an economic impact by reducing the direct costs of the impact of elders�� cognitive frailty. ""Purpose: To examine the impact of an intervention to improve the health of grandmothers raising grandchildren in parent-absent homes. Design: A longitudinal, pretest-posttest design. Methods: The sample was composed of 529 female caregivers with a mean age of 56.7 years (range 38�C83) who Isotretinoin were predominantly low-income African Americans. Data were collected prior to the intervention and again at 12 months when the intervention was complete. The intervention involved home visitation by registered nurses and social workers, as well as other support services. The Short Form-36 was used to assess physical and mental health, using eight multi-item scales. Results: A comparison of pre- and posttest mean scores on the SF-36 indicated significantly (p