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Once the METH self-administration criterion was met, the mice were subjected to extinction training before the cue-induced reinstatement test. With the extinction training, the number of active nose-poke responses gradually decreased (UMI-77 chemical structure 30?minutes after treatment with either saline or different doses of galantamine (0.1, 0.3 or 1?mg/kg, p.o.) for 3?hours. During the first saline treatment test (SAL), the mice exhibited a cue-triggered reinstatement of the METH-seeking behavior (Fig.?1b, P?Nintedanib order and 0.3?mg/kg) did not affect the increase in active nose-poking responses induced by the METH-associated cues (GAL 0.1, GAL 0.3), but a high dose of galantamine (1?mg/kg) significantly decreased the cue-triggered reinstatement of METH-seeking behavior (GAL 1) (Fig.?1b, P? effect of galantamine on the cue-induced reinstatement of food-seeking behavior, a food-intake paradigm was used. The mice acquired food-taking behavior under the FR1 and FR2 schedules and then showed an increase in active nose-poking responses in the last session of the FR2 schedule (L3/FR2), compared with that in the last session of the FR1 schedule (L3/FR1) (Fig.?2a, P? of food-taking behavior, the mice were subjected to extinction training. With the extinction training, the number of active nose-poke responses gradually decreased (CYTH4 was achieved, cue-induced reinstatement tests were performed 30?minutes after treatment with either saline or the high dose of galantamine (1?mg/kg) that had suppressed METH-seeking behavior. During the first saline treatment test (SAL), the mice exhibited the cue-triggered reinstatement of food-seeking behavior (Fig.?2b, P?