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In one study of patients with HCV genotype 3 infections who were treated with peginterferon alfa-2a and 800 mg of ribavirin for 24 weeks, SVR was achieved by 81%, 70%, and 59% when the pretreatment viral loads were ��400,000, >400,000 to 800,000, and >800,000 IU/mL, respectively; the results for patients with genotype 2 (a more responsive genotype) were 82%, 79%, and 73%, respectively.4 For genotype 1�Cinfected patients, the HCV viral load is less predictive of a response if HCV protease inhibitors are taken. For example, in a study of patients with HCV genotype 1 infections, patients treated with peginterferon, ribavirin, and telaprevir had high SVR rates despite their baseline HCV RNA levels: 78% at selleck chemicals llc randomized to peginterferon, ribavirin, and a placebo, the SVR Selleck Selinexor rates were 70% and 36% in the respective viral load groups.7 In another study of patients with HCV genotype 1 infections who were treated with peginterferon, ribavirin, and boceprevir, the SVR rates were 76% to 85% for patients with HCV RNA levels 3-mercaptopyruvate sulfurtransferase Caucasians and Asian patients, the T versus G allele at position rs8099917 provides similar information.9 The IL-28B genotype is also predictive of treatment outcomes for patients with non-1 HCV genotypes and for human immunodeficiency virus (HIV)/HCV-coinfected patients.10, 11 However, the predictive value of the genetic test is diminished in persons treated with HCV protease inhibitors. Among Caucasian patients with the CC, CT, and TT genotypes who were taking telaprevir, peginterferon, and ribavirin, SVR was achieved by 90%, 71%, and 73%, respectively (Fig. 1).12 Among Caucasian patients with the CC, CT, and TT genotypes who were taking boceprevir, peginterferon, and ribavirin, SVR was achieved by 80%, 71%, and 59%, respectively (Fig. 2).