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The Spearman correlations for the subscales ranged from 0.37 for the control subscale to 0.84 for the sexual function subscale (all P C59 wnt nmr CFI = 0.92 to sexual functioning and self-conscious CFI = 0.99). The symptom severity and energy subscales also fit the data well with CFIs of 0.99 and 0.96, respectively, however, only after hierarchical latent models were used to improve fit. Assessing the impact of uterine fibroids in women has been an ongoing challenge for researchers and clinicians. Women with uterine fibroids experience a wide range of symptoms, including heavy bleeding, menstrual cramps, and urinary frequency and urgency that are also present to some degree among normal, menstruating women. Although menstruating women have menstrual symptoms that are captured by the UFS-QOL, the UFS-QOL clearly differentiates between women with and without fibroids, highlighting the profound impact that uterine fibroids and Alisertib cost associated symptoms have on HRQL. Additionally, this study documented the responsiveness of the UFS-QOL to fibroid treatment and also documented the stability of the UFS-QOL in normal patients. The primary limitation in clinical research of uterine fibroids has been the lack of outcome measures of the symptoms and associated condition-specific HRQL experienced by two important groups, normal women in ALOX15 the same age range as fibroid patients and women who undergo hysterectomy. Without data from these benchmark groups, it is difficult to assess the comparative effectiveness of other interventional or pharmacologic fibroid therapies. The ability to compare the outcomes of uterus-sparing fibroid therapies with hysterectomy advances the use of patient-reported outcomes in the field of fibroid therapy. Given that other studies evaluating newer fibroid therapies have also used the UFS-QOL [7], [8]?and?[10], having benchmark values among normal women as well as post-hysterectomy women provides context for cross-study evaluation as well as a common outcome tool that can be used for future comparative effectiveness research. It should be noted that the UFS-QOL offers more information than the traditional pictorial blood loss assessment diary [17], which has been used in many fibroid studies as a measure of menorrhagia.