Ents. Previous studies using structural equation modeling techniques demonstrated that visual

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Previous studies using structural equation Histone Acetyltransferase Inhibitor II chemical information modeling techniques Histone Acetyltransferase Inhibitor II Histone Acetyltransferase Inhibitor II site supplier demonstrated that visual impairment was a risk factor for increasing mortality both directly and indirectly.18,19 Some possible explanations can be ZL006MedChemExpress ZL006 proposed based on literature review and on our study. Second, visual impairment itself is not only an indicator of age, but also an indicator of chronic illnesses. Risk factors for cardiovascular disease such as DM, hypertension, and smoking, have been thought to play a role in the development and aggravation of visual impairment. CKD shares common risk factors with ocular diseases and is also important risk factor of increased mortality, especially cardiovascular mortality. In the present study, a weak relation between visual impairment and mortality was found in subgroup with DM and cardiovascular disease compared with subgroup without DM and cardiovascular disease. However, visual impairment was an independent risk factor of increased mortality in the multivariable Cox regression analysis before and after propensity score matching including DM and cardiovascular disease.Ents. Previous studies using structural equation modeling techniques demonstrated that visual impairment was a risk factor for increasing mortality both directly and indirectly.18,19 Some possible explanations can be proposed based on literature review and on our study. First, visual impairment is an indicator of aging, which is directly related to morality risk. Age-related eye diseases are markers of biological aging and those ocular conditions may share a common attribute with conditions associated with increased mortality in the general population.19 In subgroup analysis of our study, there was a significant interaction between visual impairment and age subgroup in all-cause mortality. The HR of all-cause mortality was substantially higher in patients