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There was a significant increase of over 4-fold in r2* with GaD in OVB at 7?T (for [GaD] above 2?mM, p?Enzalutamide purchase of r2* knowledge at high magnetic fields, ��3?T. The comparison between r1 and r2* presented in this work is crucial in the design and optimization of high-field MRI studies making use of paramagnetic contrast agents. This is especially true in multiple compartment systems such as blood, where r2* dramatically increases while r1 remains relatively constant with increasing magnetic field strength. Copyright ? 2014 John Wiley & Sons, Ltd. ""63212" "Photoluminescent ZnO@polymer core�Cshell nanoparticles were used in mouse imaging through intradermal injections and intravenous injections, and the results proved that such ZnO fluorescence probes are nontoxic to live mice and have great potential in in vivo applications. Copyright ? 2011 John Wiley & Sons, Ltd. ""63213" "Internalizing agonists are usually selected for peptide receptor targeting. There is increasing evidence that non-internalizing receptor antagonists can be used for this purpose. We investigated whether the glucagon-like peptide-1 receptor (GLP-1R) antagonist exendin(9�C39) can be used for in vivo targeting of GLP-1R expressing tumours and compared the in vitro and in vivo characteristics with the GLP-1R agonists exendin-3 and exendin-4. Venetoclax nmr The binding and internalization kinetics of labelled [Lys40(DTPA)]exendin-3, [Lys40(DTPA)]exendin-4 and [Lys40(DTPA)]exendin(9�C39) were determined Histone demethylase in vitro using INS-1 cells. The in vivo targeting properties of [Lys40(111In-DTPA)]exendin-3, [Lys40(111In-DTPA)]exendin-4 and [Lys40(111In-DTPA)]exendin(9�C39) were examined in BALB/c nude mice with subcutaneous INS-1 tumours. natIn-labelled [Lys40(DTPA)]exendin-3, [Lys40(DTPA)]exendin-4 and [Lys40(DTPA)]exendin(9�C39) exhibited similar IC50 values (13.5, 14.4 and 13.4?n m, respectively) and bound to 26?��?103, 41?��?103 and 37?��?103 receptors per cell, respectively. [Lys40(111In-DTPA)]exendin-3 and [Lys40(111In-DTPA)]exendin-4 showed rapid in vitro binding and internalization kinetics, whereas [Lys40(111In-DTPA)]exendin(9�C39) showed lower binding and minimal internalization in vitro. In mice, high specific uptake of [Lys40(111In-DTPA)]exendin-3 [25.0?��?6.0% injected dose (ID) g?1] in the tumour was observed at 0.5?h post-injection (p.i.) with similar uptake up to 4?h p.i. [Lys40(111In-DTPA)]exendin-4 showed higher tumour uptake at 1 and 4?h p.i. (40.8?��?7.0 and 41.9?��?7.2% ID g?1, respectively). Remarkably, [Lys40(111In-DTPA)]exendin(9�C39) showed only low specific uptake in the tumour at 0.5?h p.i. (3.2?��?0.