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Screw length, plate length, plate angle and osteoporosis were calculated at 0 stars and can be considered a minor factor when designing the optimal DDP fixation system. Combining with the main effect plot for bone/plate/screw stress and fragment displacement (Fig. 5), plate thickness with 1.8?mm, plate width with 6?mm, screw diameter with 2.8?mm (in head) and fixation with two screws in proximal fragment were chosen for the optimal DDP fixation design. Although plate angle was a minor contributor, three angles (0��, 30�� and 60��) of L plate were collected as the essential factor in plate optimisation to fit the surgical consideration (different radius fracture configurations) for biomechanical testing. The stress distribution for the 18 simulation models was also determined. Simulation results showed that stress patterns for bone and plate/screw were similar. Fig. 6 shows one on behalf of the typical selleck products simulated stress distribution model. During cyclic testing no catastrophic failure occurred for any of the constructs. No gross visible screw loosening or volar cortex displacement was observed. The average stiffness in 2000 and 20,000 tests cyclic were 412.3?N/mm and 425.7?N/mm for the 0�� constructs, 459.6 and 461.1?N/mm Sitaxentan for 30�� constructs and 509.1?N/mm and 532.1?N/mm for 60�� constructs. For statistical analysis, no difference in stiffness was found in the same angled constructs throughout the 20,000 cycles of testing (p?>?0.05). However, significant differences (p?RG7204 concentration this fracture type favoured surgical operations.22, 23?and?24 There are numerous internal fixation techniques implemented by surgeons and each of them has specific advantages and disadvantages according to the original development concept and specific indications. Dorsal locking plates have the intuitive advantage of acting as a buttress to posterior comminution. However, an optimum technique should not only restore wrist alignment biologically but also regain the joint function biomechanically (i.e., MIS). This study investigates the biomechanical interactions of DDP using a locking fixation system for multifactorial parameters including osteoporosis levels, engineering design factors and fixation methods to identify the importance of each parameter and suggests an optimised DDP fixation system for in vitro experimental verification. Despite the extensive use of FE analysis and its acceptance as a complementary tool for examining detailed mechanical responses in many biological studies, model sensitivities to variations in input parameters or possible interactions between parameters have seldom been evaluated. Dar et al.