Exposed: This Is Why PF-01367338 Would Make You Much Happier

32 We found opposing libertarian and utilitarian views on food fortification. There is accumulating evidence that universal vitamin D food fortification can improve serum 25-hydroxyvitamin D levels,33�C36with recent studies investigating novel methods of supplementation37�C40 However, food fortification on a national basis may be unviable if a large proportion of the population disagrees on principle.41 42 Arguments were similar to those against fluoridated water,33 with freedom of choice, coercion, safety implications and trust issues commonly highlighted. Summary Our findings highlight the need for easily accessible reliable information for the public about vitamin D, and clear, detailed public health messages about sun exposure. Public health messages about sun exposure and vitamin D need to differentiate between the advice for the general population and those at high risk of vitamin D deficiency.43 Lay interest, medicalisation and clinical uncertainty may fuel recent increases in testing and prescribing of vitamin D. Plans for food fortification would need to address its unacceptability among a significant portion of the population. Acknowledgments The authors thank Jack Dunne for prescribing data, Pete Timms for testing data, the participants and their general practice. Footnotes Contributors: AM and CG conceived the study. They elaborated the design with MS, DG, NJ and SK. SK, DG, NJ, RS and CG analysed the data. All authors interpreted the data. SK and CG wrote the manuscript, which was critically reviewed by all authors. CG is the guarantor. Funding: This is a summary of independent research funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research Programme (Reference Number RP-PG-0407-10398). Competing interests: None declared. Patient consent: Obtained. Ethics approval: Camden NHS Research Ethics Committee. Provenance and peer review: Not commissioned; externally peer reviewed. Data sharing statement: No additional data are available.""Cardiovascular disease (CVD) is the leading cause of mortality globally1 and CYTH4 accounts for about a third of all deaths in Ireland.2 Dyslipidaemia, especially hypercholesterolaemia, plays a major role in the development of CVD. Evidence from randomised controlled trials has estimated that a 1?mmol/L individual level reduction in low-density lipoprotein cholesterol (LDL-C) is associated with a 20�C25% reduction in CVD mortality and non-fatal myocardial infarction, regardless of an individual��s initial lipid profile.3 4 Lipid-lowering drugs include statins, fibrates, bile acid sequestrants, nicotinic acid and selective cholesterol absorption inhibitors. Statins not only reduce LDL-C but halt progression, and may contribute to regression of coronary atherosclerosis.