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The exclusion criteria are: TURP/prostatic salvage cryosurgery/HIFU performed more than 6 months before registration, previous prostatectomy, http://www.selleckchem.com/products/cx-5461.html androgen deprivation therapy within 3 months prior to registration, performance status ECOG > 2, International Prostate Symptoms Score (IPSS) > 20, PSA doubling time Forskolin ic50 (bDFS), overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS), and clinical patterns of tumor recurrence (time to local tumor progression or distant failure), as well as pre-treatment prognostic and/or predictive factors. Sample size considerations The sample Sitaxentan size is calculated with type I error of 0.025, type II error of 0.2 (power of 80%), and a one-sided hypothesis (only excess of cases is of interest). Conservatively assuming a ��normal�� rate of 10% grade 3 or higher late toxicity, 70 patients are needed to exclude that the rate is actually �� 20%, i.e., unacceptable, with the necessary precision. This sample size calculation is based directly on the binomial distribution. Adjusting the number of cases for ineligible or unanalyzable cases by 10%, a minimum sample size of 77 patients is required for this study. Brachytherapy Implantation procedure The implant procedure will be performed according to the standard technique. A Foley catheter will be inserted to visualize the urethra at the beginning of the procedure. The patient will be positioned in the lithotomy position, centered on the table. The ultrasound probe will be inserted into the rectum and adjusted to provide a satisfactory image without distorting the contour of the prostate. Row #1 on the template matrix is positioned within the prostate on the axial image, on which the prostate is most posteriorly situated and is anterior to the rectum at all levels. Afterloading catheters may be placed with TRUS or MR guidance. The implant catheters must be non-metallic (for hyperthermia use).