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Obviously, dryocrassin ABBA exerted a significant dose-dependent antiviral effect in mice. The survival rates were 87, 80, and 60%, respectively in the 33, 18, and 12.5 mg/kg dryocrassin ABBA groups. In contrast, mice administered amantadine hydrochloride showed 53% survival while only 20% mice remained alive in the untreated group (Figure ?Figure2A2A). Furthermore, a significant increase in body weight gain was observed in the dryocrassin ABBA-treated groups compared to the amantadine-treated group and the untreated group (Figure ?Figure2B2B). FIGURE 2 Therapeutic efficacy of dryocrassin ABBA in mice infected with see more influenza virus A/Chicken/Hebei/706/2005. (A) The mice survival rate post administration with 33, 18, 12.5 mg/kg of dryocrassin ABBA or 20 mg/kg of amantadine hydrochloride. The infection ... The Effects of Dryocrassin ABBA on Lung Index and Virus Loads Post inoculation with H5N1 virus on day 7, mice infected with influenza virus exhibited a significantly greater lung index compared to the control group (P ... The Effects of Dryocrassin ABBA on BALF Cytokine Levels MCP-1 and IL-10 increased significantly while IL-12, IL-6, IFN-�� and TNF-�� decreased significantly in the 33 and 18 mg/kg dryocrassin ABBA-treated groups compared to the amantadine-treated group and the untreated group on day 7 (P