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In group A, implants were inserted with bicortical stabilization, at >35?Ncm torque (under-drilling protocol); and in group B, with Adenylyl cyclase Two implants (one of each group) were implanted in the right tibia under aseptic conditions in all animals. Similar procedure was performed in the left tibia 21?days later. All animals were euthanized 42?days after the first procedure, both tibiae removed and processed for non-decalcified histology, stained with Toluidine blue. Crestal bone to implanted contact (c-BIC) and total BIC (t-BIC) were evaluated and calculated. A paired non-parametric test (Wilcoxon test) was used to evaluate differences between groups. P?Microbiology inhibitor as significance level. Results Three weeks post-surgery the mean c-BIC in group A was 16.3?��?3.3% vs 31.5?��?3.4% in group B (P?BIBF 1120 molecular weight implications Despite the gap between implant and bone present at time of insertion, at early healing stages, cBIC was significantly higher in implants placed with over drilling protocol and low insertion torque compared to those with under-drilling protocol and high insertion torque. At later stages a smaller difference was noticed and was not statistically significant. This study suggests further investigation of bone healing dynamics surrounding implants inserted under high insertion torque. ""E. Huttner, D. Cantarelli machado, J. Antunes de lima, C. Mottin PUCRS, Porto alegre, Brazil Background Morbid obesity is a serious health condition can interfere with basic physical functions such as breathing or walking. This disease increases the risk of diabetes, hypertension, sleep apnea, gastroesophageal reflux disease (GERD), gallstones, osteoarthritis, heart disease and cancer. After bariatric surgery, patients usually require plastic surgery and demand for dental rehabilitation. With in its indications and limitations metabolic and bariatric surgery leads to weight loss and metabolic changes que podem influenciar na osteointegration. Aim/Hypothesis The aim of this case report is to explain and discuss the literature and laboratory investigations on the metabolism of the patient with a history of bariatric surgery interest in osseointegration.