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In our study we were able to identify early ulcers as deep depression in mucosal surface or areas of low T1 and high T2 signal intensity causing disruption in the mucosal layer. Deep ulcers were identified as being extended into the submucosal layer. Comparison with barium enteroclysis was beyond the scope of our study. The cardinal principle behind obtaining diagnostic small bowel images is good distension and opacification of the bowel lumen coupled with ultrafast MRI sequences and intravenous contrast. Distension of the small bowel can be achieved with intubation (MR enteroclysis) or non intubation (MR enterography) techniques. The intubation technique can provide detailed luminal information yet its advantages have been counter balanced by the complexity of the procedure, patient discomfort and the need for sedation (27). The non intubation technique is another technique where a large volume of oral contrast medium is PF-02341066 ingested by the patient prior to imaging. In our study we use this technique, it is less complex, less uncomfortable for the patient, it produces good opacification of bowel although it may not be optimal and uniform as compared with the enteroclysis examination (27). There are limited studies that compare MRI findings with small bowel inflammation, but they suggest that contrast enhancement intensity correlates with intestinal inflammation. MRI data that combines both bowel wall thickening and signal intensity has previously demonstrated greater accuracy in assessing disease severity (28). In view of these observations patients in our study were classified according to intestinal wall enhancement and bowel wall thickening on MRI. Our findings suggest that the small bowel MRI findings can be used to categorize CD patients and that these categories correlate with patient response to ongoing medical therapy. No significant differences were detected between the medical therapy regime used and the response/remission rates overall, or between any of the MRI categories suggesting that the medical therapy was not primarily responsible for differences observed in the response rates. In our study females were more likely to respond to medical therapy than males. The reason behind this was unclear but may be attributed to that in our study sample, females were more than males (60%:40%) In our study patients without luminal narrowing were more likely to respond to medical therapy (P?