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, 2002). Participants generated on average 85.37 ideas (SD?=?31.34) in the divergent thinking see more tasks. An analysis of the time course of old and new ideas (the 60-s task was separated in four successive 15-s epochs) revealed that the total rate of ideas generally decreased over time, F(2.25, 88.38)?=?83.89, p?PIK-3 shorter for old ideas than for new ideas (M?=?6.69 vs. 8.73?s; SD?=?2.72 vs. 3.08), t(34)?=?6.83, p?Small Molecule Compound Library t(34)?=?1.57, p?=?.13, or response duration (M?=?1.67 vs. 1.70?s; SD?=?0.53 vs. 0.59), t(34)?=?0.68, p?=?.50. Divergent thinking (OLD & NEW?>?0) was related to activation of a left-hemispheric frontal network, involving the left inferior frontal gyrus (IFG) and superior frontal gyrus (SFG) extending medially to the left insula and putamen (BA 46, 47), and of a cluster encompassing parts of the hippocampus and inferior temporal gyrus in the right hemisphere (BA 20). Further relevant regions of activation included the left precentral and postcentral gyri (BA 3,4,6), subgyral regions of the right frontal cortex and a cluster in the right posterior cerebellum (see Table?1, and Fig.?3). The reverse contrast (OLD & NEW?