Life, The Demise Or AG-014699

A whole-brain analysis revealed widespread activity throughout the brain for the main effect fear, but the frequently reported contrast fearful?>?neutral faces did not reveal any significant clusters. Selleck AG-14699 Repeatability of signal amplitude was low (Quetiapine is comparable to previously reported outcomes (Plichta et al., 2012, Stark et al., 2004?and?Van den Bulk et al., 2013). Spatial repeatability could be increased with physiological noise correction to an ICC of about .45, which is still lower than repeatability in the fusiform gyrus. However, it is important to acknowledge that the size of the fusiform gyrus mask favors spatial repeatability compared to the amygdala, since it largely extends beyond the active volume and therefore introduces more variability of the signal within the regarded ROI. Similar results were found when spatial repeatability was calculated for group-level activation. The ICC was higher within the fusiform gyrus (ICCs?>?.80) than in the amygdala (ICCs?selleckchem a result of more variability of group activation level within the fusiform gyrus. Our group-level repeatability in the amygdala is slightly lower than previously reported by Plichta et al. (2012) who used a different emotion task and implemented a block design. Physiological noise correction did not improve repeatability of the BOLD response amplitude. The correction decreased the variance of the fMRI time series in the gray matter by about 15%, which means that physiological parameters are likely to have affected the BOLD response. There are several possible explanations for why the repeatability was not improved.