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Версія від 08:19, 20 червня 2017, створена Drawer9parade (обговореннявнесок) (Створена сторінка: Differential diagnosis The differential diagnosis for a 6-year non-progressive [http://www.selleckchem.com/products/PF-2341066.html find more] gastric ulcer is...)

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Differential diagnosis The differential diagnosis for a 6-year non-progressive find more gastric ulcer is H pylori-associated ulcer and MALT lymphoma. Treatment The patient refuses further investigations including a follow-up staging and additional surgical treatment. Discussion SRC of the stomach was reported to have more aggressive behaviour than other types of early gastric cancer such as deeper invasion depth, larger tumour size, positive lymphovascular invasion and positive lymph node metastasis. The SRC histology tends to have diffuse type of Lauren's classification of gastric cancer.2 However, a larger tumour size of early gastric cancer with signet ring?cell histology may lead to earlier diagnosis than gastric cancer of other histological types.3 The overall 5-year survivals with appropriate treatment including surgery and chemotherapy according to the cancer stage were 96%, 84%, 49.2% and 3.8% in patients with SRC stages I, II, III and IV, respectively.4 SRC has long been thought to confer a worse prognosis. Without appropriate treatment, the gastric carcinoma, especially poorly differentiated carcinoma with signet ring cell, rapidly advances. There was only one prior case report of a 74-year-old Korean woman with early gastric cancer with signet ring?cell histology who deferred a distal subtotal gastrectomy for 53?months after diagnosis. The surgical pathology showed SRC with submucosal invasion with no lymph node metastasis, which was compatible with stage IA.3 Our case with poorly differentiated gastric carcinoma with signet ring?cell stage at least IA had an unexpected non-aggressive course of the disease without any treatment. The prolonged course could also be due to earlier diagnosis as known as ��lead time bias��. Our patient also took alternative medications effects of which were not exactly known. Learning points Typically, signet ring?cell carcinoma (SRC) has an aggressive behaviour and provides poor prognosis without any treatment. Appropriate treatment after SRC diagnosis including surgery and chemotherapy are necessary to extend the course of disease. The history of SRC-type gastric cancer in untreated patients, who survived longer than 5?years, is scarce. Our case is an exceptional history of gastric SRC. Footnotes Contributors: PP participated in drafting the article. RP and NW participated in revising the article critically for important intellectual content and final approval of the manuscript published. RR participated in revising the article critically for important intellectual content and submitting the article. Competing interests: None. Patient consent: Obtained. Provenance and peer review: Not commissioned; externally peer reviewed.""A 60-year-old male patient presented with a history of shortness of breath for 4?months and low-grade fever for 1?month.