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3) With the gradual shrinkage of the tumor during the treatment, one or more capsules of 125I seeds may become detached; therefore, it is recommended that the patients have regular checkups. For metastatic spinal tumors, simple local radiation therapy was previously used. Although a good pain-relieving effect was achieved,4 some studies have suggested that compared with simple radiation therapy, radiation therapy combined with spinal decompression and spinal fixation can relieve pain more effectively and improve the quality of life.9 Vertebroplasty and vertebral column RO4929097 mw decompression fixation are common surgical methods of treating metastatic spinal tumors. In recent years, 125I seed implantation combined with vertebroplasty and vertebral column decompression fixation has become a new therapeutic technique for metastatic thoracolumbar tumors. Compared with the individual treatment approach, this combination method has a more satisfactory clinical efficacy. There are more reports on vertebroplasty combined with 125I seed implantation. Nutlin-3 mw For example, Yang et al10 used 125I seeds combined with percutaneous kyphoplasty to treat metastatic spinal tumors. The preoperative average VAS score was 8.4 points, and one day after surgery, the average score dropped to 2.9 points. One week after the surgery, the average score dropped to 2.0 points, and the average score dropped to 1.5 points 6 months after the surgery. Huang et al also reported that vertebroplasty combined with 125I seed implantation had excellent therapeutic effects in the treatment of metastatic thoracolumbar tumors.11 The numerical rating scale pain score at the time of follow-up after 2 months of surgery dropped from the preoperative score of 7.12��1.48 to 2.26��1.07, and the pain relief effect was significant. Rogers et al12 reported that the permanent implantation INPP5D of 125I seeds wrapped in resorbable materials to treat metastatic paraspinal tumors had significant pain-relieving effects; in addition, particle implantation could enhance the local lesion control. Although simple radiation therapy can partially relieve pain, this therapy cannot effectively relieve the mechanical pain caused by the compression of tumor tissues. In addition, this therapy cannot solve the problem of spinal cord instability caused by pathological vertebral fracture and cannot relieve neurological symptoms. Simple radiation therapy is mainly suitable in the following cases: 1) inability to tolerate surgery or a predicted survival time of