Navitoclax Clinical Trial Results

Other studies have similarly purchase AZD-7762 price highlighted the role of Notch1 in epithelial differentiation [20]. This role for Notch1 in differentiation is similar to that in other stratified epithelia such as the epidermis and intestinal epithelium where loss of Notch1 also leads to an impaired barrier function [38,39]. These results provide additional insight into the phenotype of Notch1-/- miceNotch1 and Corneal Epithelial BarrierFigure 4. Aqueous tear production is increased and 10457188 goblet cells are intact in conditional Notch1-/- mice. Aqueous tear measurement by phenol thread test in millimeters at baseline, 2 and 4 weeks after treatment with 4-OHT in Notch1-/- and WT littermates. The mean aqueous tear production 16574785 in Notch1-/- eyes was found to be significantly higher than WT at 2 (7.4 ?2.3 mm versus 3.6 ?1.4, P = 0.001) (N=10 per group) and 4 weeks (10.5 ?1.8 mm for Notch1-/- compared to 2.7 ?0.9 mm in WTs, P