Відмінності між версіями «Nded on experimental basis, represents an additional discontinuity point with respect to»

Версія за 08:17, 27 лютого 2018

Offered that homeostasis is dramatically threatened or even disrupted within the course of a number of illnesses, to understand such processes we're obligatory required to apply ML-128 web methodologies that discover nonlinear spatiotemporal systems with various levels of structural and functional organization. This will result in models of tissues and organisms with enhanced predictive energy [114]. Second, tissue and cytoskeleton/nucleoskeleton architecture, as well as mechanical forces (stiffness, shear stress [115], and surface tension), should be adequately weighted and investigated, a rather unusual request to get a "traditional" biologist [116]. Third, molecular and genetic modifications, involving each the epithelial and the stromal cells, should thus be investigated in association and linked towards the observed modification in the context. While significantly has been learned about molecular elements and subcellular processes, the integration of information and models across a wide range of spatial and temporal scales, taking us from observations in the cellular or subcellular level to understand tissue level phenomena, remains an unchartered territory. Moreover, biophysical influences on cell behavior and differentiation might be adequately appreciated only by studying cells in their three-dimensional context and are thus disregarded by existing experimental methodologies practically completely depending on 2D cultures.Nded on experimental basis, represents a different discontinuity point with respect to SMT which posits that "biologicalinformation" carried out by genes constitutes the only (or the principle) causative element in driving cellular fate and behavior.5 levels. This can result in models of tissues and organisms with enhanced predictive energy [114]. Second, tissue and cytoskeleton/nucleoskeleton architecture, also as mechanical forces (stiffness, shear pressure [115], and surface tension), has to be adequately weighted and investigated, a rather uncommon request to get a "traditional" biologist [116]. Third, molecular and genetic changes, involving each the epithelial and also the stromal cells, should really hence be investigated in association and linked towards the observed modification of the context. While considerably has been discovered about molecular components and subcellular processes, the integration of information and models across a wide array of spatial and temporal scales, taking us from observations in the cellular or subcellular level to understand tissue level phenomena, remains an unchartered territory. Additionally, biophysical influences on cell behavior and differentiation may be adequately appreciated only by studying cells in their three-dimensional context and are as a result disregarded by existing experimental methodologies virtually completely according to 2D cultures.Nded on experimental basis, represents a further discontinuity point with respect to SMT which posits that "biologicalinformation" carried out by genes constitutes the only (or the primary) causative aspect in driving cellular fate and behavior.five levels. This will result in models of tissues and organisms with enhanced predictive power [114]. Second, tissue and cytoskeleton/nucleoskeleton architecture, at the same time as mechanical forces (stiffness, shear strain [115], and surface tension), have to be adequately weighted and investigated, a rather uncommon request for a "traditional" biologist [116]. Third, molecular and genetic modifications, involving both the epithelial and the stromal cells, really should thus be investigated in association and linked to the observed modification with the context. Despite the fact that much has been discovered about molecular elements and subcellular processes, the integration of information and models across a wide selection of spatial and temporal scales, taking us from observations at the cellular or subcellular level to know tissue level phenomena, remains an unchartered territory.