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With regard to complications, deep vein thrombosis, pulmonary embolism, and procedure-related complications were examined, and the latter included wound complications, hematoma, lacerations, and disruption of the treated organs by instrumentation or manipulation (T81�CT87) [25]. In this database, disability status was assessed by the Barthel index Carfilzomib mw (BI) score at admission and at discharge. BI at admission was grouped into the following categories: BI VX-809 concentration hospital volume and academic status were examined. The former was categorized into high-, intermediate-, or low-patient-volume hospitals; each group had an equal number of patients. Academic hospitals included university hospitals, the National Cardiovascular Center, and the National Cancer Center, which are involved in educating medical students and postgraduate trainees and clinical research. The dependent variables were change in BI, LOS, and total hospital charge (TC; 1US$ = 100 yen) billed during admission as a proxy for total cost [28]. In Japan, the delivery of hospital services is determined by a standardized fee-for-service payment system known as the nationally uniform fee table. In this study, TC included physician fees, instrument costs, laboratory or image test costs, and administration fees. Deceased patients were excluded from this analysis. Categorical variables were presented using numbers and proportions by rehabilitation initiation categories and tested using the chi-square test. Continuous variables were reported as mean and standard deviation and compared by analysis of variance. Dependent variables were LOS, TC, and BI improvement as outcomes. A multiple logistic regression analysis was used to determine the effect of study variables on the selection of rehabilitation. To reduce the selection bias of the indications for rehabilitation, we used a propensity Cefaloridine score matching method (one by one) and compared again the resource use and outcome by the use of rehabilitation [21]. To control for the hospital location and the variation in every hospital practice for multidisciplinary treatment, study hospitals were handled as random intercepts in three mixed linear study models [11]?and?[12]. Model 1 attempted to identify the impact of rehabilitation provision on dependent variables of BI improvement and TC compared with no rehabilitation. Model 2 measured the impact of early rehabilitation initiation on BI improvement and TC among the rehabilitation group.