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17 (P = .002) (Table 4). As a result, medications that delayed MRI progression for 10 years would be associated with a 1.7-point increase in preference rating, higher than that of any improvement in symptoms, if considered over 10 years. Patients preferred preventing disease symptom progression slightly less than progression measured by MRI lesions, with each year of progression prevention providing an increased relative preference rating of 0.12 point (P Dolutegravir research buy daily symptoms. Patients strongly preferred once-daily oral medication administration compared with all other combinations of injectable routes and frequencies of administration. The preference for an oral agent, even when taken daily, showed a stronger preference rating than, for example, moderate improvement in symptoms. Injecting subcutaneously three times weekly was least preferred, resulting www.selleckchem.com/products/obeticholic-acid.html in a preference rating 1.41 points lower than oral administration (P CDK9 orally or that has the potential for a rare but substantial improvement in symptoms. Patients indicated that they would be willing to accept a much higher risk, a 10% or 30% risk of severe adverse effects or death, for a medication that prevented progression for 25 or 32 years, respectively. Demographic Characteristics and DMT Preferences Comparing the descriptive statistics of age, sex, time since RRMS diagnosis, marital status, and current DMT in the mixed-effects model revealed several variations in risk acceptance.