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001, uncorrected). Figure 1 The decreased glucose metabolism regions in DM (P CGK 733 The cluster size >50 voxels. The color bar indicates the T-value. Small-world topology of the functional networksThe brain functional networks of both the DM group ... Small-world topology of the functional networks The brain functional networks of both the DM group and the NC group had the characteristics of ��small-world�� networks (�� > 1). For example, at all of the density thresholds, both networks had a large normalized cluster coefficient (�� >> 1) and a normalized characteristic path length close to 1 (�� ~ 1; Figure ?Figure22). Figure 2 Normalized cluster coefficient (��), normalized characteristic path length (��), and small-world index (��) in DM and NC. (A) The �� from NC and DM. p click here characteristic path length �� was significantly longer in the DM group than in the NC group (density threshold: 10%; Figure ?Figure2B),2B), and the small-world index �� was significantly smaller in the DM group than in the NC group (density thresholds: 10�C22, 34, 36�C40%; Figure ?Figure2C)2C) (P Trichostatin A order plausible (Bassett and Bullmore, 2006; He et al., 2008). To identify the hub regions, we measured the normalized betweenness centrality in both networks (see Section Data and Methods). The DM had 21 hub regions (Table ?(Table4),4), and the NC had 19 (Table ?(Table5).5). The two groups shared five hub regions (Figures 3A,B). We used a 1000 non-parametric permutation test and obtained seven hub regions with significant differences between the DM patients and NCs (P