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Statistical significance was set at P BMS-354825 in vitro based on the area under the curve (AUC) was described as follows: AUC = 1.0, perfect diagnostic accuracy; 0.9 symptom score was 27.3 �� 23.4. Acid reflux, non-acid reflux, and no reflux were observed in 13 (21.0%), 5 (8.0%), and 44 (71.0%) patients based on MII-pH, respectively (Table 1). There were no differences in the presence of typical reflux symptoms, globus symptom intensity, or psychosomatic symptom scores between the 3 groups. Pathological laryngeal changes was observed in 49 (79.0%) patients with no differences between the 3 groups. Most patients (59 of 62, 95.2%) showed no mucosal break at the distal esophagus. Mucosal breaks were identified in only 3 patients, as follows: 1 grade A esophagitis and 1 grade B esophagitis in the acid reflux group and 1 grade A esophagitis in the no reflux group. There were no significant selleck products differences among the 3 groups with respect to age, gender or BMI. Table 1. SAR1B Comparison of the Acid Reflux, Non-acid Reflux, and No Reflux Groups in Patients With ghe Globus Symptom (N = 62) Comparison of Impedance Baselines Between the Acid Reflux, Non-acid Reflux, and No Reflux Groups The acid reflux group showed a lower IB compared with the no reflux group at 3 cm (1612.85 �� 656.66 �� vs 3087.73 �� 854.76 ��, P