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44% (95% CI: 5.07 to 7.82%) for the fixed versus 6.47% (95% CI: 5.12 to 7.82%) for the randomized presentation, showing that the slopes by mode of presentation overlap considerably. Similarly, for the 6-channel vocoding, for every unit increase in SNR, SRS increased by 5.47 (95% CI: 4.29 to 6.64%) for the fixed versus TSA HDAC nmr 6.65% (95% CI: 5.13 to 8.18%) for the randomized presentation. FIGURE 3 (A) Performance-intensity functions (mean plus 95% confidence intervals) are shown for the 16-channel (open circles) and 6-channel (closed circles) vocoded sentences measured during the physiological test session where SNRs were randomized. (B) Performance-intensity ... Table 1 Results for the linear mixed-effects models. Figure ?Figure3C3C shows the mean effort ratings measured after each of the fixed SNR sentence blocks. There was no interaction between SNR and channel vocoding (p = 0.26, Table ?Table11) indicating no evidence of a different pattern of effort over SNR between the two channels. Excluding the interaction term, LME regression confirmed that perceived effort averaged over channels significantly decreased (p selleck chemicals llc was used to examine the effect of vocoding (conducted during different test sessions) on alpha power during baseline. No significant difference was found between16- and 6-channel vocoding (mean difference = 0.69 mcV2, 95% CI: -1.47 to 2.85, p = 0.53). This suggests that overall, participants had similar PTEN alpha power baselines on both test sessions. Alpha Power Change and SNR Alpha power was processed as a relative change from baseline in noise, for each trial. A LME regression model suggested a significant interaction effect between SNR and channel vocoding on alpha power change (p = 0.01, Table ?Table11). Specifically, for the 6-channel vocoding, there was no evidence of a change in alpha power over the different SNRs (0.01%, 95% CI: -2.38 to 2.41%); p = 0.99) while for the 16-channel vocoding, for every unit increase in SNR, alpha power decreased by 4.34% (95% CI: 1.94 to 6.73% decrease; p