Perhaps You Also Make Those Same Blunders With The BGJ398 !

A breakthrough IFI wad defined as any IFI diagnosed after ��3?days of EAFT, as proposed in a study by Walsh et?al. [7] comparing caspofungin and liposomal AmB in patients with persistent fever and neutropenia. Galactomann blood index (threshold 0.5, enzyme-linked immunosorbent assay, Ag Aspergillus; Bio-Rad. Hercules, CA, USA) was measured once a week in the bone marrow transplantation unit and chest computed tomography (CT) was performed before the transplantation. No routine diagnostic procedure was performed in other units unless an IFI was suspected. If information was missing in the medical, laboratory and/or nurse charts, the medical team was interviewed to collect the missing data. Pharmacology parameters were also recorded regarding Fluconazole the doses, intervals between administration buy BGJ398 and length of treatment for each antifungal agent. If a patient was treated for two or more distinct episodes of fever and neutropenia during the 3-month study period, each episode was analyzed independently. Overall, 56 EAFT episodes among 49 patients were retained for analysis (seven patients had two separate febrile neutropenia episodes). Forty-four patients were male (90%) and the median age was 41?years (range 15�C76?years). Forty-five patients (92%) were hospitalized in the haematology or oncology unit, four in the intensive care unit. Thirty-one patients (63%) were treated for acute leukaemia (25 acute myeloid leukaemia and six acute lymphoid leukaemia), seven (14%) for lymphoma and 11 (22%) for other haematologic conditions. Fourteen patients (29%) were allogeneic haematopoietic Selleckchem Paclitaxel stem cell transplant (HSCT) recipients and five (10%) had undergone an autologous stem cell transplant. Antifungal prophylaxis (oral fluconazole in all cases) was prescribed in 23 patients (47%) after the administration of chemotherapy and before the beginning of the EAFT. EAFT was started because of persistent fever despite broad-spectrum antibiotics (22 episodes, median duration of fever 7?days), recurrence of fever after transient apyrexia under antibiotics (27 episodes), clinical signs of sepsis with temperature