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The study concluded that the introduction of solid foods before 4 months was not associated with an increased risk of obesity in adulthood; however, the review was not systematic and the conclusions were based Capmatinib upon the outcome of only five studies (Sass 2006). Therefore, the aim of the present study is to address these gaps by undertaking a systematic review to investigate whether there is an association between the timing of introducing solid foods, and obesity in infancy and childhood. This review did not find an association between the timing of introducing solid foods and obesity in infancy and childhood. The Cochrane Library and the Database of Reviews of Effectiveness were searched, as well as other online databases: Medline, Embase, CINAHL, PsycINFO, British Nursing Index, and Archives and Maternity and Infant Care. The search strategy was generated selleck kinase inhibitor directly from the review question, which was broken down into key facets using the Population-Intervention-Outcomes-Design (P-I-O-D) model, as shown in Fig.?1. For each of the facets identified using the P-I-O-D model, possible synonyms, spelling variants and subject headings were identified. A preliminary search was conducted using the search terms to ensure the sensitivity and specificity of the search strategy. An initial search was conducted in 2007 and was updated in December 2008 and July 2010. Limits were applied for English language text and studies on humans. The search did not include grey literature. Quinapyramine No date restrictions were applied for the initial search; however, date restrictions were applied to the updated search (Table?1). Hand-searching of reference lists of retrieved articles was also conducted. Papers from citations identified through the search strategy were retrieved for pre-screening when titles and abstracts met the pre-defined inclusion criteria. Randomized, observational and case-control studies were included and reviews were excluded; studies included in reviews were assessed. Only studies of participants living in developed countries were included to ensure that the review was applicable to these populations. Countries were defined as developed according to the World Development Report (World Bank 2001). No restrictions for sex or ethnicity were implemented. Studies of pre-term infants (born at