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False Discussion A 1999 meta-analysis8 concluded that smokers were up to three times more likely to experience placental abruption and/or placenta praevia than non-smokers. Regarding smoking cessation, 92 there is substantial evidence to support one-to-one and group-based psychological interventions. True 93 motivational assessment is the final stage in smoking cessation services. False 94 interventions lead to a quit rate at follow-up of up to 50%. False Discussion First-line intervention for pregnant women on initial diagnosis of nicotine dependence involves ��motivational�� assessment, interviewing and individual or group-based ��talking�� therapy. With regard to quit rates, [http://www.selleckchem.com/products/VX-809.html www.selleckchem.com/products/VX-809.html] see Table?2 in the article. Nicotine 95 is metabolised 30% more quickly in pregnancy. True Regarding smoking cessation, the National Institute for Health and Clinical Excellence recommends 96 considering nicotine replacement therapy for those expressing a clear wish to receive it. True 97 advising women not to remove nicotine replacement patches at [http://en.wikipedia.org/wiki/Resminostat Resminostat] night. False Discussion In their guidance NICE26 recommend advising women to remove patches at night to avoid continuous fetal exposure to nicotine. Regarding pharmacological therapy, 98 bupropion and varenicline are contraindicated for use in pregnancy. True If nicotine replacement therapy is used in pregnancy, 99 it should be used early and discontinued by the second trimester. True Maternal smoking 100 is not known to be associated with gestational diabetes. False Discussion See Table?1 in the article. ""If you intend to claim CPD credits you should submit your answers online using the TOG CPD submission system of the College website (http://www.rcog.org.uk). Please log into the website to use the TOG CPD function, which can be found in the ��Our profession�� section. The RCOG Guidelines on which [http://www.selleckchem.com/products/Bafilomycin-A1.html this website] some of the questions are based are also available on the College website. There is no longer a deadline for submission of answers to CPD questions. Risk factors for uterine rupture in women undergoing trial of labour include: 1 age