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Immunostained slides were scored after the entire slide had been evaluated by light microscopy. For all specimens, negative control was adjacent non tumor of specimen and positive control was on kit of stain. HER2 immunostaining was evaluated using the same method as was employed by the HercepTest (DAKO). To determine the score of HER2 expression the membrane staining pattern was estimated and scored on a scale of 0 to 3+. Tumors with selleck kinase inhibitor scores of 2 or greater were considered to be positive for HER2 overexpression. The expression status of p53 and Ki67 was assessed according to the estimated proportion of the nuclear staining of tumor cells that were positively stained. Scoring criteria for p53 were as follows (in the form of the proportion of nuclear staining = score): None = 0, 1/2 = 3. Scoring criteria for Ki67 were as follows (in the form of the proportion of nuclear staining = score): None = 0, 1/2 = 4. Tumors with a score of 1 or greater for p53 were considered to be positive for p53 protein accumulation, and tumors with a score of 2 or greater for Ki67 were considered to be positive for Ki67 expression. Statistical analysis Collected data were documented using the Statistical Package for the Social Sciences version 20.0 (IBM Corp., Armonk, NY, USA). Statistical analysis was done using descriptive statistics. Results were expressed as percentages, frequencies, and mean �� S.D. The Mann�CWhitney U test, ��2 test, Pearson Chi-square test, or Spearman Rho test were performed for Thymidine kinase comparative statistical evaluations among groups and for correlation ABT 737 analysis with histological and clinical parameters (tumor size, tumor grade, lymph node involvement, metastasis rate, coexistence of HER2 overexpression, p53 protein accumulation, Ki67 expression, and postoperative survival). Survival periods were counted in months from the date of the first visit to date of death or last follow-up before study closure. We used Kaplan�CMeier method to estimate the overall survival for low and high levels of HER2 overexpression, p53 protein accumulation, and Ki67 expression. A P value of