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The control group comprised those cases who did not receive antibiotic therapy. In general, fever is an objective symptom for the evaluation of infectious diseases. For the analysis of the potential benefits of antibiotics, we recorded the duration of hospitalization and the patient's clinical course related to fever, including the number of febrile days before and after admission. SPSS for Windows (version 17.0; SPSS Inc., Chicago, IL, USA) was used for the data analysis. Descriptive statistics were performed, with continuous variables summarized as the median and range, and categorical variables summarized as the frequency and proportion. The Chi-square test or Fisher's exact test, or a non-parametric test was used to assess differences between two groups. The prevalence of the samples was compared VAV2 with the Chi-square test for linear trend. Statistical significance was set at p Tyrosine Kinase Inhibitor Library mw ward beds and 53 intensive care unit beds, providing primary and tertiary care for infants and children in southern Taiwan. The annual emergency department census in this hospital is approximately 55?000 visits. The clinical microbiology laboratory and medical records center databases were reviewed in order to identify patients with enterovirus infections during the period January 1, 2008 to December 31, 2012. During this period, there were 3664 admission episodes for infants and children with herpangina and HFMD. The laboratory data including CRP level and total WBC count were available for 3566 out of 3664 episodes; thus 98 of 3664 episodes were excluded from this study due to a lack of clinical and laboratory information. Antibiotics were prescribed in 537 of the 3566 episodes (15%). Finally, a total of 214 episodes (6%) were enrolled in group C on the basis of our criteria and were then evaluated further in a demographic and descriptive study. learn more Although group C was the least populated group in our study, it had the highest consumption of antibiotics (71.0%, 152/214), compared with groups A (8.7%, 236/2701) and B (22.9%, 149/651) (Figure 1). There was a significant linear trend (p